I use the Focusrite Scarlett 18i20 . It has been great with no exception period. BIAB used it fine until I updated Windows. ...... I had been using BIAB directing fron the USB hd.
I never had problems with USB and firewire with a Fireface 800 and a RME UFX. With Windows 7 64bit.
Then Firewire and USB problems arose when i upgraded windows 10 from within windows 7. So then i did a fresh new Windows 10 64bit installation, stripped from a lot of consumer features of course, and it seemed to run far better and smoother, probably due f.i. a skimmed registry.
Now i experience USB problems, thus with windows 10 only, and especially RME UFX ii USB drivers. These seem to be related to the motherboard's x99 chipset
and/or ASmedia USB chips, i installed a now obsolete ASUS u3s9 PCIe card with a NEC USB 3.0 chip, and my UFX ii works better it seems, no dropouts or distortion as i had before.
BTW these windows 10 - USB issues could be related to your Graphics card too; get the latest drivers, and don't use those gamer 's tune up tools and utilities, just the basic drivers ..
MOTTO IMO: Windows 10 can be darn fast, but it STILL sucks. F