I use Real band and "Scuffham S gear" (like amplitube etc.) guitar plugin and have played live through the input monitor with surprisingly little latency, though there seems to be no way to automate the plug in (for patch changes or whatever). If there was a way to have an "Input monitor track", a possible solution offered up by one of PG's gracious techs, It could be that would solve the problem. For instance, if your playing through live and need a patch change at bar 48, you could program that in and leave the peskey pedal board at home. Cleaning up the gig (no amp or pedalboard), so one can be more attentive to their audience is always a good thing! Love PG! I've been a user since way back in the Atari days! Thanks loads!

Max
No need to welcome you to the programs, but welcome to the forums anyway.
Best
Trevor

Hey, Thanks Trevor! I hope my contribution to the wish list doesn't sound too crazy. Seems simple to me and I think would be handy. The best to you, Max

Some FX do change if a MIDI signal is routed to them.
Some have a 'MIDI Learn' function that may be of use.

I have no experience with "Scuffham S gear"

It does appear there some available methods:

http://www.scuffhamamps.com/forum/search?query=MIDI&titleonly=1&childforums=1
Scroll to the post with an image ..

Seems others would like the 'MIDI Learn functionality for that plugin:

http://www.scuffhamamps.com/forum/8-wishlist/7272-midi-learn#10504

Chime in and see if they can add it.