I just found out what it is!

When I open the song ALL of the volume instruments are set to zero (0) and Pan is -63.
Well, again, I opened the Pref / MIDI Drivers as described in my original post and click ok. BAM!!! all of the volumes are at 90 now and my Pan(s) are set correctly

Now that is really wierd.

I agree with you Matt, I think it is time to try the return to factory settings..

Thanks.

Mark