Plenty of experiments show musicians aren't objective listeners.
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THIS!
I'm a trombone player and a member of the trombone forum.
When the pBone (a plastic trombone) first came out there was a lot of interest and two opposing views soon became very obvious.
Predictable there were the lovers and the haters.
The lovers could see the potential for a practically indestructable trombone ('bone slides are SO fragile), that weighs next to nothing yet still sounds very good from in front I.E. what the audience can hear.
The haters mostly would not even bother to consider them worth trying, let alone allowing that they might even sound acceptable.
The reality is not that simple:
1) From an audience perspective, it is pretty well impossible to hear any difference, as shown by blind recordings. The sound is mostly determined by a) the players natural sound and b) the SHAPE of the air column - particularly the bell flare.
2) From the players perspective it is more complicated. Most of what a trombone player hears is NOT what's coming out of the bell of the instrument, but what radiates from the BACK of the bell and the tubing near the players left ear. This makes the MATERIAL the instrument is made from critical to the player, BUT NOT THE AUDIENCE. Anything that changes the way the bell vibrates changes what the player hears.
OK, so which side is right - I reckon BOTH are, but from different points of view.
One thing is certain, some players quickly get comfortable with the change in aural feedback and some don't, but this does not affect the audience who can't hear that feedback anyway.
Another thing is that a significant section of the trombone playing community "listen with their eyes" I.E. "it's plastic so it must be cr@p". An example of where this is inconsistent is I bet not one of them can tell the difference between the sound of a wooden and a plastic clarinet.
For myself (I own several pBones of different colours), I MUCH prefer to play brass because the better aural feedback makes it easier for me to play and because the feedback is more "lively" than from plastic I don't tend to overblow the horn.
So when do I use my pbones?
a) for novelty value - it often "wow's" audiences with the bit of fun it creates, especially when they hear how good they really sound (there's less bias there)
b) when I want to have a bit of fun
c) introducing people to a trombone without fear the natural clumsiness that comes from holding something unfamiliar won't damage my expensive brass horns
d) MARCHING - these things are sooo light in comparison to brass that I will NEVER march a brass horn again.
Sooo, even if you can get all the deficiencies of 3D printing sorted when related to the instrument (eliminating rough sides for the air column etc.) you are STILL going to get haters who only listen with their eyes.