If I missed the recommendation to try Return to Factory Settings, I apologize. But Noel's interesting suggestion about the file keeping track of plugins should be tried as well. It would not be reset by Return to Factory Settings, to my knowledge.
BIAB 2019 Win Audiophile; [& 2019 Mac UltraPak]. Software: Cakewalk, Adobe Audition, Ozone, Encore; Win 10 64 Pro. Hardware: custom i7, 16 Gb; Roland Integra-7, Focusrite 18i20(2), TCE Finalizer, Behringer X-Touch, Adam sub & monitors.