The speakers shouldn't matter.

The answer is in how you set up your interface.
It can be used for input or output or both.

For example I often use my Focusrite as an input and the MAduio as output.
Just hook the speakers up to wherever the sound is routed to. You'll find it in the Audio Prefs section. Could be the Focusrite, the Windows out or maybe the Bose.

It's possible the Bose Minilink connects as it's own output device .. you've mentioned a few routing possibilities with no real guideline on how you plan to use them.

TBH, that speaker system looks geared more toward mobile devices (to me) than as an audio monitoring system for music software.
I'm guessing that in order to use ASIO you'll connect those speakers to the Focusrite audio outputs, probably via an adapter.

Make your sound your own!
.. I do not work here, but the benefits are still awesome