Wow Larry - that's the kind of insightful response I like to an open-ended questions - I learn things I didn't even ask.

I have:
Presonus Firepod
Old Guitar Effects processor DOD G7
Boss VF-1
Roland Gi-20 Synth controller
TC Helicon Voiceworks.
GT10 guitar effects
Kore2 Controller

I realize I don't necessarily have to have all hooked up at any given moment - and studio use is different than live.

I'd like to be able to:
1.) Plug my guitar in and use ANY effects for recording, and recall sets of effects used for particular songs ; same for vocals
2.) easily be able to play songs with different sounds/setups and get to them with one setting
3.) play any synth sound that NI has through my guitar via GI20, and record into BB/RB through presonus.

Open ended - how would some of these things be optimized to work together in the most integrated, useful way ? I'll bet I my equipment can do things in cool, logical ways I haven't even thought of.