Well, sort of.

If you use the key signature drop-down control (just left of the tempo control), the song will regenerate and continue playing in the new key. However, there will be a pause to regenerate. The more RealTracks you use, and the less powerful the computer, the longer the pause.
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BIAB 2017 PC Audiophile. Software: SONAR Platinum, Adobe Audition, Ozone, Encore; Win 10 64. Hardware: custom i7, 16 Gb RAM; Roland Integra-7, Focusrite 18i20 (2), TCE Finalizer, Behringer X-Touch, Adam sub & monitors.