I think REAPER handles vst, vsti and vst3 better than any other DAW I have used. If you are using REAPER 64bit then any 32bit vsts are automatically bridged in REAPER with no need for jbridge. The designers have also announced that Melodyne ARA support will soon be available. Mixcraft is powerful though and offers loads of instruments and effects. Acoustica is a great company and they support their products well.