As an example of how different a song can sound, even when the chords are the same:

the song DECEMBER by Collective Soul starts with the same pattern as While My Guitar Gently Weeps, but the melody and instrumentation are so different you might not even notice that the chords are basically the same.

Listen along and in your head sing the lyrics to the Beatles song. It works.

https://www.youtube.com/watch?v=6exsatE-DUk

The chords to the whole song aren't the same.. but I offer this as an example of how discretionary changes to a chord pattern can create a totally different feel.