Blake, sorry for the delay in responding.

First my BinaB is 2022 for Mac and I have all the updates.
The chain is guitar into a focusrite then into the Mac
The display text read as follows:

- There was an error during audio recording. The error code is -50 [16-8-22 14:14:16]
- There was an error during audio recording. The error code is -50 [16-8-22 14:14:16]
- Time to scan unknown VST plugins = 0 ms [16-8-22 14:08:49]
- Time to scan known VST plugins = 1 ms [16-8-22 14:08:49]
- Time to scan AU plugins = 38 ms [16-8-22 14:08:49]
- Time to scan ALL plugins = 39 ms [16-8-22 14:08:49]
- Scanning for plugins... [16-8-22 14:08:49]
- TMacAudioInput.StartInputThread: success [16-8-22 14:08:49]
- Bootup was optimal, set to fast [16-8-22 14:08:48]
- Bootup time in millseconds =20,960 [16-8-22 14:08:48]
- macOS version 10.12.7 [16-8-22 14:08:36]
**** New Session started at : 16-8-22 14:08:36
- 63% of the chords have been re-interpreted using Natural Arrangement feature to common chords, improving the arrangement. (You can turn this feature off globally in Arrangement Options, or for song in Song Settings.) This message shows once per session. [15-8-22 13:42:26]

It seems that I can get the signal from the Focusrite into the BinaB.

Not sure if I have to use some type of plugin to record into the program?

As mentioned, I can record throught my DAW, but this is something that is an option for me to record.

BinaB 2023 for Mac all updates current.
Focusrite Saffire pro 40