Yes, it is in 'E'. Great tune, one of the best blues instrumentals of all time in my opinion.

You won't be able to get it exact in BIAB, but you should be able to find something with a close enough feel, just key in the chords, set the tempo, and start auditioning styles. Hardest part might be that changeup in the middle where it does the double time thing.

Anyway, an interesting project! If you guys do something with it I would love to hear the results