And then there is what you can do with a classical guitar, detuned and then lead line played on same guitar. I did this as an experiment some years back as part of the February Album Writing Month.

Guitar was a $150 solid cedar top 'valencia' model which really digs being tuned down significantly. Pickup came in the guitar from a company called Shadow. The bass line, rhythm guitar and lead were all that Valencia model. The wah was a freebie VST from GSi.

https://soundcloud.com/rockstar_not/detuned-rockstar_not

I think I tuned down to C or C#, can't remember - this was several years ago.

The GSi was called Effectizer, available still for free in GSi's legacy-ware page:
http://www.genuinesoundware.com/?a=showproduct&b=37