with 12 bar blues and the guitar i do a couple of things.

vary the key as well as them tempo. over time this will help you a great deal in seeing the entire fretboard.
licks you may know in one position will start to reveal themselves on other places.
Its a mystery particular to relatively few instruments besides the guitar.
That whole same note in 3 different places thing.

vary the style of the blues. a swing vs a boogie woogie will have you using different chords when you comp.
you'll certainly play different lines when you solo.

Try to never never NEVER play a song faster than you can comfortably play it while you are learning it.
There will come plenty of time to break this rule and embarrass yourself later onstage.

Sometimes playing a song much slower than at speed will show you where there is some "room" between phrases.
It might open up some new ideas, especially with your solos

Never resist the temptation to play a rest. Its the most overlooked note in our arsenal.

biab2023(Mac)
Logic Pro X