You mentioned earlier you were using MME with the Focusrite.
This is not recommended.
Use the Focusrite USB ASIO drivers.
Also the Phenom II processors were made between 2008 and 2012, making them a little long in the tooth.

I had a Phenom II system until the end of last year, the system it was in also had dated USB connections from the same era and could not keep up with the needs of the Focusrite 18i20.
The older system could handle the 2i2 just fine, but the 18i20 was enough to make it show its weaknesses

I built a newer Ryzen system using the ASUS ROG platform and all my problems went away. Plus I have a faster machine with lots more USB options now.

By using the existing case and hard drives the new machine was about $500 including W10 license.
FWIW in my mind I had good experiences with Focurite on other machines, and decided to keep the interface and upgrade the machine.

Make your sound your own!
.. I do not work here, but the benefits are still awesome