Guitar (Strat) - Alesis Q2 or Zoom2000 (for echo patches) - OCCASIONAL addition of Boss CS-3 for LIGHT compression/sustain - Joyo ACTone (Vox amp sim) and then straight to DAW,
The ACTone is REALLY, REALLY good: convincing, versatile and reliable too. The Behringer BDI21 is similarly excellent for bass.
Both make the point that SANSAMP/TECH21 do fabulous work but charge WAY too much.