Hi rharv:

Thanks for your answer, it happen when open a new and there is not the option on my settings to open the last file.
What do you mean with "likely something in the configuration" ?

Secondly, the Akai LPK 25 would be an external controller and is really not affected, also my other sound controllers via USB wound be a problem: B4000+, Mojo Desktop, M-Audio Oxygen Pro or NC2X.
What I missed are the driver of my sound card, which occasionally I wanted to use directly without starting all the external controllers.
As I wrote my sound card is a simple one Creative Audigy 5 Rx, so when I start PT the midi drivers are not seen in Midi Devices (Preferences), only the Microsoft GS Wave Table Synth.

Thanks for any thought about this issue.