One trick I use playing fast over complex changes is to try to simplify the changes.

For example a 2-5-1 can easily be thought of as a 5-1. Others suggest it is a 2-1. Either way its 33% fewer changes and either approach sounds good.

Also you ignore as many of the upper partials (9,11,13, natural, sharped or flatted) as you need to stay up with the changes.
Focus your initial arpeggios on the root, 3rd, and 7th of the chord. Add some chromaticism, approach from above or below and you have the start of a pretty good solo.
Often those upper partials are part of the melody. You may or may not want to focus on those tones in your solo anyway.

Target the 3rd of the chord you are moving into as your first note. Not every time, but it always sounds good.

Ignore some of the more complex harmonies. A tri-tone subsitituion on a dominant chord is a cool outside sound. I love it and use it a lot.
But ultimately its a 5 chord (dominant7) resolving a 5-1 cadence. Treat it as a dominant 5 chord and leave the tritone stuff for later.

The great guitarist Joe Pass often stated he thinks of only 3 chord qualities- Major Minor and Dominant.
Great advice.
It may not get you through every song, but it helps to keep up when the changes are flying fast and furious.

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