I see no reason to run more than one AV program at a time. I've heard this is not a good idea - whether technical or marketing I don't know. MSE has been out for a while and most here seem to have no problem with it either. In fact, it was just upgraded to V2. Using MSE with a spyware scanner like Malwarebytes is my choice. Like Matt, MSE has not let anything through on my machines according to Malwarebytes scans.

R