Matt touched on the most important one:

MIDI does not support Chords, whereas Music XML does.

You really need to define (for yourself) exactly what your requirements are, and then explore what each option provides to fulfill those needs.

BTW: I'm certainly not advocating that MIDI is the lesser solution. Music XML is extremely verbose. MIDI, as a data structure, is extremely elegant.

If your score needs chords displayed, Music XML might be the best option. If not, and you are looking for maximum flexibility, MIDI might be the best direction.


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