It should ask for the 3 folder locations bb-RealTracks-Drums
there should be an option Don't Ask Again.
Might be the same with your ASIO you have unplugged the usb device ???

After you have closed RealBand with all the correct settings, create a folder in the RealBand folder "Config Backup"
list the RealBand folder by newest date
copy RB.CFG RealBand.INI DEFAULT.RWS with all the correct settings to that folder.
Now you have a backup.
Add the text below under Code: to a text file, rename it RealBand Reset My Defaults.bat
Now just run the bat file to start RB with your saved settings.
You can right click Run As Administrator if any problems.

Code:
del "c:\RealBand\RB.CFG"
del "c:\RealBand\RealBand.INI"
del "c:\RealBand\DEFAULT.RWS"
copy "c:\RealBand\Config Backup\DEFAULT.RWS" "c:\RealBand\DEFAULT.RWS" 
copy "c:\RealBand\Config Backup\RB.CFG" "c:\RealBand\RB.CFG" 
copy "c:\RealBand\Config Backup\RealBand.INI" "c:\RealBand\RealBand.INI"

start "" "c:\RealBand\RealBand.exe"

exit


This way you can start RB in any mode or settings you like, just save another lot of settings to another folder "Config Backup2" and create another bat/exe for it.

You can convert the bat file to an exe file with an icon
http://www.softpedia.com/get/System/File-Management/Batch-To-Exe-Converter.shtml
At the Bottom of the post right click save RealBand2017.ico.png rename RealBand2017.ico
or add any icon you like, search "icons" google or create your own.

In Bat to EXE Options > Miscellaneous > Administrator Manifest
Click Compile to create the RealBand Reset My Defaults.exe
You can pin it where you like or create a shortcut.

Attached Files (Click to download or enlarge) (Only available when you are logged in)
RB_Paths.jpg (62.49 KB, 43 downloads)
Reset_Realband.jpg (126.42 KB, 137 downloads)
Reset_Realband2.jpg (141.78 KB, 129 downloads)
RealBand2017.ico.png (3.19 KB, 129 downloads)