I have no knowledge of the PreSonus, so can't help you with that.

However I have been using the 2i4 here for a few years now and I can tell you it is a very good interface, I love it. Perfect for recording both vocals and guitars (line and instrument level inputs).

EDIT: Maybe this will help: https://www.careersinmusic.com/best-audio-interface/

Last edited by BlueAttitude; 04/28/19 12:53 AM.