I have never experienced any issues after rendering in Reaper. Having said that I’ll often render leave it for a day or so listen again and maybe redo it. I have found I do that a lot less since using Tonal Balance Control (a part of Izotope Ozone Advanced).

I did put up a link https://m.youtube.com/watch?v=JwDcTPn2dvc yesterday. This really covers the basics in Reaper. I also recommend going to http://www.kennymania.com/reaper-videos/#reaper-5-explained
When it comes to Reaper Kenny Gioia is the man. This site has everything you need to know and then some about Reaper.

Tony


HP i7-4770 16GB 1TB SSD, Win 10 Home,
Focusrite 2i2 3rd Gen, Launchkey 61, Maton CW80, Telecaster, Ovation Elite TX, Yamaha Pacifica 612
BB 2022(912) RB 2022(2), CakeWalk, Reaper 6, Audacity, Melodyne 5 Editor, Izotope Music Production Suite 4.1