Matt,
I think Alyssa means adjusting graphics to benefit performance and not quality. Sometimes that makes Gui a little edgy.
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I will add a few to the list:

*If you have a spinning drive, upgrade to SSD.

*Make sure your bios is up to date!

*Run a free Latency checker program Latencymon. If Latencymon has red bar(s), see which driver(s) produces highest latency in the system. Perhaps try reinstalling that driver.

*If you tried most things above and still have dropout issues, try switching to Airplane Mode (disables Wifi / bluetooth) Network drivers are notorious audio enemies.