I don’t use a Focusrite interface but make sure you have ASIO set as the Reaper Audio Preference. (Options = Preferences = Device).

Also do not have a heap of plugins loaded. For example, Ozone will cause a huge amount of latency but then again why have it until after recording.

Just a thought

Tony


HP i7-4770 16GB 1TB SSD, Win 10 Home,
Focusrite 2i2 3rd Gen, Launchkey 61, Maton CW80, Telecaster, Ovation Elite TX, Yamaha Pacifica 612
BB 2022(912) RB 2022(2), CakeWalk, Reaper 6, Audacity, Melodyne 5 Editor, Izotope Music Production Suite 4.1