I've had a similar problem still not resolved. I hit play and it won't play on any song file I open old or recent. I got some pop up about the sound card driver but it would close to quickly for me to read it. I even tried to recreate the pop-up while videoing the screen so I could freeze frame and read it. I updated the driver for my Behringer UMC204HD and still same problem. Finally, I disconnected UMC204HD and started using the headphone output just to keep moving forward with my song schedule.
I do take my computer to remotely work on music with the UMC204HD disconnected at times and I'll have to mess with the soundcard settings to get sound out of the headphone jack and then mess with things again to get the UMC204HD to work again.

Now, I had assumed this problem was caused by either a (Realtek High Definition Audio) soundcard conflict with the UMC204HD or a defect in the headphone out jack that detects when I plug or unplug a jack there. I have to wiggle the cable at that jack to make good connection to the headphone cable or output cable.
Since reading this post I'm thinking it might be related to that latest Reaper update but I don't really know.
Also thinking it might be a problem in the UMC204HD and I'll have to replace it but don't want that expense right now especially if I don't know exactly what's causing the problem.
For the past several days I've had the UMC204HD disconnected and so far no issues. But, I'm going to start recording audio soon and need this problem solved.
So, if anyone does know a solution I'd be greatful to have suggestions before I start spending time to figure it out.

Does the noise in your head bother me ?