I'm the one needs to delete the preference every time or is not able to reopen the software. Under the safe mode, everything works, but it is not for a long term.

For plugins, I have

Komplete 12 (native instrument)
Keyscape (spectrusonics)

Otherwise, nothing installed.

How long is PG music supposed to fully resolve the problem of the stabilities under Big Sur?
MacBook Pro 2020/Cubase 10.5/Komplete 12 Ultimate/SpecSonic KeyScape