Be sure to adjust the latency and buffers for audio and midi.

That's the first step to take.

Second and very important question.... what sound card and driver are you using?

Normally the factory sound card in any off the shelf computer isn't really designed to work well in "our world" of multi-track recording. And the driver they tend to use is designed to play one MP3 track at a time. We, on the other hand, are working with wave files, and software synths in multiple tracks and we need all that music from various tracks to get to the speakers at the same time.

Often, the factory setups are not up to the job. Since they can't handle it, they start dropping notes to keep up and when that doesn't happen, often the midi tracks are out of sync with the audio tracks which can be out of sync with each other as well.

The solution is to first try adjusting the settings as I described. If that doesn't work, an external USB audio/midi interface that runs a native ASIO driver will normally fix the issue. In my studio, that was the solution I had to use. Now, everything is flawless and my latency is 5ms.... in other words.... you can't hear it during playback.

You can find my music at:
www.herbhartley.com
Add nothing that adds nothing to the music.
You can make excuses or you can make progress but not both.

The magic you are looking for is in the work you are avoiding.