Those delays are minor and vary a lot by DEVICE - some have very little some have a lot but remember anything under 8-9'ish ms you won't even notice and depending on what your use the last item FOR in a long chain like that, you may have no appreciable drawbacks, .e.g., if you used one of those sound modules for mainly pads or slow attack sounds anyway you'd never notice in actual use if it was last and other units before it had minimal delay in tote.

TRY it! Even with DRUM Module at end just to actually see how much delay you really do HAVE (is it noticeable). A drum beat e.g., Snare rim strick or bass drum hit is probably the best audible indicator of how much affect your chain really has at that point

You could play around with the order of your modules (with keyboard always being first) and see which unit has most noticeable delay and put it at END of chain like that.

=========

I have a lot o gear so I use a patch bay (actually two of them) one feeding the other. All "controllers" (4 keyboards and 2 MIDI guitar units and the PC attached to first patch bay and each can trigger the other via that patch bay and/or send MIDI to second patch bay to trigger none, one, some, all of the midi modules attached there and the second patch bay is the path back to the PC so I always have a MINIMUM of THREE MIDI devices in "chain" from PC to patch bay to one of the units to its patch bay then back to PC via second patch bay (again that's minimum for me) and in actual use I have never had a "timing" issue (that was appreciable).

Good Luck

Larry

Win10Pro,i9,64GB,2TBSSD+20TBHDDs,1080TI,BIAB'24,Scarlett18i8,Montage7,Fusion 8HD,QS8,Integra7,XV5080,QSR,SC-8850,SPLAT,FL21&others,Komp.14,IK suite&others, just a guitar player-AXE FX III &FM9T, FishmanTP, MIDIGuitar2, GK2/3'sw/GI20