Update and possible root cause.

My Studio One problem still exists and a thought came to me, could Guitar Pro be the problem. So I shut down GP and lo and behold, the circular activity mouse icon in Studio One changed back to the normal pointer and full functionality returned.

So then I queried my AI assistant and it gave me this.
Yes, Guitar Pro can sometimes cause issues with other programs that use the same digital interface. Users have reported that when Guitar Pro is open, it can interfere with other applications that use the audio driver, such as Skype, Zoom, or even YouTube. This is often due to how Guitar Pro handles audio drivers and its interaction with the system's sound settings.
Here are a few tips to mitigate these issues:
1. Use ASIO Drivers: If you're not already using ASIO drivers, consider installing them. ASIO4ALL is a popular choice that can help manage audio routing more effectively.
2. Check Audio Settings: In Guitar Pro, go to the "Audio/MIDI Devices" settings and ensure the device is set to "Standard" instead of "ASIO" if you're experiencing conflicts.
3. Virtual Audio Cable: Using a virtual audio cable program can help with routing audio between different applications.
4. Consistent Sample Rates: Ensure that all your audio applications are set to the same sample rate to avoid conflicts.
These steps should help you manage any potential conflicts between Guitar Pro and other programs using the same digital interface.

Item 2 may be relevant because that setting in GP is set to "ASIO" but I'm planning to change it to "Standard" as it suggests.

I'm not claiming victory quite yet, but I think I'm getting close. Either way, hopefully this thread will be of use to someone else in the future.

And holey mackrel! The more advanced technology becomes, the more advanced the problems!

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BiaB 2025 Windows
For me there’s no better place in the band than to have one leg in the harmony world and the other in the percussive. Thank you Paul Tutmarc and Leo Fender.