One thing that makes it hard to help you is you seldom really answer the questions we ask. You never responded as to what PTE4 is, Powertracks 4 was made many years ago but the picture looks like a newer GUI. Just because the soundcraft has as you said a really good driver that does not mean that it works well with PTW. On one screen shot you have multiple inputs highlighted, but USB from a mixer is usually stereo only. In other screenshots a couple are highlighted this could be the issue, but when we make suggestions and you don't follow up. Do this and let me know what happens.

1. Unplug the mixer
2. open PTW and go to options/return to default
3. open preferences and go to audio, choose MME, choose the input and output for your computer.
4. Load a new demo song (BB folder / Realtracks demos)
5. Generate and play.

Comeback and tell us what happens. Just remember this stuff can be easy but at the same time not all drivers are created equal. I have seen many cause serious issues over the 25 years i have been using software recording software. The folks here will go a million miles to help you but you have to help them help you!

HP Win 11 12 gig ram, Mac mini Sonoma with 16 gig of ram, BiaB 2025, Realband, Reaper 7, Harrison Mixbus 9 32c , Melodyne 5 editor, Presonus Audiobox 1818VSL, Presonus control app.