Note: This only applies to Vista, and only when User Account Control (UAC) is enabled.
Yes, the problem is due to Windows Vista, and its Account Control (UAC) feature.
Vista Security seems to go into full paranoia mode with a program 'daring to run' from a USB drive, without explicit permission from the user and Vista. Sheesh.
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If you are having trouble running the programs from the USB hard disk, you may need to do one of the following.
1. Turn User Account Control (UAC) off. To do this, go to Control Panel | User Accounts, and click on the item "Turn User Account on or off"... You will need to restart the computer.
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2. Installing the program to the hard drive (leaving the RealTracks on the USB Hard drive).
Once you disable UAC, the program runs great.