Almost every time I will turn the synths into audio before mixing.
Makes the job simpler to me when having to deal with only audio.
Adds the option of routing effects to AUX effects possible.
Allows editing of any little sections I want ('add delay to synth in chorus' type stuff)

Of course, this is after I am happy with the synth part. And I always keep the MIDI track just in case I want to go back; I just mute it. MIDI tracks take up very little space.

I do not work here, but the benefits are still awesome
Make your sound your own!