This sort of sounds like a physical problem like a failing component on the motherboard or the power supply. Lets hope that's not it because good luck tracking that down if it doesn't happen all the time. The only way to test this is start with the easiest things like your cables and work up from there like disconnecting your Presonus and run the audio from your onboard soundchip. If you still get this then I would look at the power supply first. Wavering voltage from a failing PS can cause all sorts of weird things then it finally goes completely and it can toast your system.

Bob


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