You left it on for 14 hours? Was RB open that whole time? Did you start changing things in RB settings before the first reboot?
I always reboot before every session, One of my habits.

Your ASIO being very loud may be in the routing inside the MOTU mixer, maybe it's feeding back thru .. just an idea. Those soundcard software mixers can get confusing; there is a playback level (monitoring) and another input feed level (to computer) .. and if that computer input comes back out added into the original signal it can be disconcerting (like the pun?).

The EMU routing (patchmix) on some cards was such a pain to me I disqualified it. Others here use this system, and trying to undo what they did while trying to 'fix' something would have been a nightmare. Maybe MOTU ASIO has that level of complication; I dunno.
Just trying to help ya bud, those are the things I see from your post that stuck out to me. I'd be sad to see you go, after you've had so much success with many features. You were using some pretty complex devices and setups. And getting stuff done. Something changed.

I do not work here, but the benefits are still awesome
Make your sound your own!