I used to regularly disconnect my US 224 without issue as I used it both on my desktop and laptop. However, I am scrupulous about using the same port as Mac mentioned. Obviously I have to unplug when I move my laptop.

Incidentally, I also had a problem with the system occasionally "losing" the interface and having to reinstall the drivers. I have no explanation for that, nor do I have one for why it stopped doing it. Just in case I keep all the install files and drivers in a folder on the desktop of my DAW. Your system should stabilize once you get the basics ironed out and are using it on a regular basis.

Sounds like you have a nice system. Let us know how things go.

"My primary musical instrument is the personal computer."