As I work primarily in MIDI I haven't done more than poke a stick at RB. RB works well as far as it goes, but I think it lacks certain automation and effects capabilities which I am used to. Workflow used to be BIAB 200x ported into Propellerhead Reason 3, then Rewired into Steinberg Nuendo (Cubase's big brother). Now that Reason 6+ has incorporated audio it has become my primary sequencer. Theoretically I can do things in two steps instead of three.

There are various limitations which necessitate the use of more than a particular set of software. PG products don't have Rewire and only partially implement VST technology. Reason functions as a Rewire slave only and doesn't use VST at all. My old version of Nuendo won't run on my new DAW (dongle won't fit, and it may not run on a 64-bit system anyway). Now that I have BIAB/RB 2012.5 I can see myself making more use of RB for drums, but I still need Reason for its soft synth and advanced effects capabilities. (That MIDI thing, don't y'know.) I'll try to stick to PG products and Reason for a while, but if I ever truly need Rewire I'll have to include Reaper or another Rewire-equipped sequencer.

If you're curious about what Rewire is and why it is important to me, check out this brief article on the Propellerhead website. It has been on the PG Wishlist for some time. I think that once you grok it you'll want it too.

"My primary musical instrument is the personal computer."