I've made tracks that didn't throw any red flags in my music room, but they sounded muddy through a PA. No doubt it was muddy in my studio too, but I was so happy with the idea of finishing the project I wasn't listening with discerning ears.

Interestingly, my MIDI tracks don't tend to sound muddy through the PA... they actually sound better, maybe because the sound is being generated in real time as though somebody was playing the notes through the synth.

The audio tracks were probably muddy because I didn't take time to isolate the frequencies. There were also probably a lot more tracks and therefore more opportunities for frequency overlap. ( Mixing is my weak link.)