When a song is mixed and mastered properly it will survive; and should unless an un-natural amount of compression or eq is added, you could destroy even the most perfect sounding symphony with compression. but that would happen with any song no matter how well it were recorded and mastered if you crush it it loses its life. If you notice the professional songs on youtube hold the sound when you listen. Where as a lot of home made mixes do not, because they were not sonic to begin with and when you crush a poor mix it only sounds worse; because it had no sonic space to start with and crushing it only makes it worse; take it from me I have made some stinkers. A good example of this is radio, radio stations compress everything, but it is in a way that acts as an eq as well; so it keeps the sonic value, however if you listen to a mix on the radio that is not done professionally or by a qualified engineer it will sound awful. What makes great sonic recordings great is the fact that they were mixed great and mastered to perfection to begin with.

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Psalm 57:7 My heart, O God, is steadfast, my heart is steadfast; I will sing and make music.