If it is a HD version, just use the factory's hard drive....

But aside from that, yes, you should be able to install it onto any external or removable drive with the capacity to hold it.

I ran it for several years (in the past) on an external USB backup hard drive, and it ran quite well. That was when I was on a lappy and didn't have the room on the laptop HD for BB/RB.

You can find my music at:
www.herbhartley.com
Add nothing that adds nothing to the music.
You can make excuses or you can make progress but not both.

The magic you are looking for is in the work you are avoiding.