Lots of good comments and observations already so I'll pretty much leave it at that.

I found myself wondering what, exactly, "He" was doing or not doing. I thought you could have put several lines in there describing somewhat of his behavior that lead her to that place and time. Just a thought for the future because I know you're not going to go back and rewrite a verse just for this.

Yes, I especially like the way you craft the meter of the melody in the lines.

The guitar at the beginning is off to a good start.... (talking about your live one) Not what I'd call a signature lick, but certainly a really appropriate intro fill. I tend to use fills a lot. Someone mentioned Bob Segar's Main Street.... Yes, now that's a superb example of a signature lick, it starts the song and shows up throughout the song. Toward the end it starts to variate a bit but keeps the overall feel and tone regardless. Wonderful Tonight is another great classic signature lick that plays throughout the song by Clapton.
On the lead in your song, as the song rolled on, however, I found the lead to be a bit distracting as it played behind the other tracks in a few places. It wasn't in too many places so it's not a big deal. It was more like a meandering series of notes relying on the FX for it's dramatic effect. The easy solution is to mute it in the balance of the song. However, I do think that a proper, nicely crafted signature lick for this song would really set it off nicely. Signature licks tend to be pretty simple melodic riffs that will fit well in numerous places in the song and gives it a musical cohesion apart from the lyrics or anything else.

As always, I'm picking out the really small details because everything else on this song is so well crafted.

Well done my friend.

You can find my music at:
www.herbhartley.com
Add nothing that adds nothing to the music.
You can make excuses or you can make progress but not both.

The magic you are looking for is in the work you are avoiding.