I have everything music (BIaB, Reaper, SampleTank, National Instruments, ...) on my E-drive without problems. On the C-drive there is only that stuff that needs to be in Common Files, Program Files and Program Files (x86).


Desktop; i7-2600k, 8 GB mem., Win 10 Pro, BIAB 2017; RB 2017 - latest build
Laptop: i5-2410M, 4 GB mem, Win 10 Pro, BIAB 2017; RB 2017 - latest build