Not sure what you are trying to accomplish, but........What I do on many occasion, is

1. Find a midi file that I like
2. Convert the midi track or tracks to audio
3. Use audio effects such as compressor, reverb, delay etc to shape the sound
4. I often will then have Real Band generate an instrument on one or more tracks

This can be for solos, comping, or fills, such as sax or resonator guitar.

5. Mute the midi tracks, and play all the audio thru my sound source or sources.
6. Do the first mix, adjust any effects such as too much reverb etc.
7. Do the final mixdown, and pre master stage
8. Master finishes

A converted midi to audio file if tweaked properly can sound very much like a real instrument, be advised it will not be a real instrument, but will be closer than using just a midi sound. This especially applies to certain instruments like guitars.

Strings and sometimes pianos can do quite well with midi. I convert those anyway, just so I can eq them and compress them the way I want.

Dang....This is addicting.

http://www.reverbnation.com/roberttrippmusic