Herb, it seems that Russ is already running his mixer(s) via USB:

"I'm running my mixers through a USB port. I've got a digitizer attached to the mixer that plugs into the USB ports."

I believe that is the root of his no-sound issue to begin with since he has the mobo-based Real-Tek selected (so it seems) as his default output device.

When he says he 'gets no midi' there's another issue to contend with - Russ hasn't said whether he means midi i/o to external devices, or no midi playback from a computer-based midi GM synth (which used to be all the rage when Russ was last regularly active on these forums years ago).

Russ, be a little more specific and it will help to diagnose your issues.

1. Where are your amp/speakers connected - to the USB mixer or to the speaker output of the MOBO/Real-Tek? Whichever that is has to be selected as your audio output device in Windows and in BIAB.

2. What are you referring to with MIDI - GM synth (drums on ch 10) kind of MIDI, or you can't get MIDI I/O from/to a MIDI keyboard or external sound module/synth?