The Bose 301s and any of Bose's 'Direct/Reflecting' speakers would be very challenging speakers to use as monitors.

Here's a photo of the 301 model with the grille removed. You can see that the drivers point every which way - which might fill a room with mid and high frequency sound, but that is not what one wants with monitor speakers. The point of monitors is to direct sound right at your listening position, not off axis to your position.

I'm a fan of Bose in general. For many years, I used Bose 401 and then 801 speakers as main speakers for a choir I was in and also ran sound for in the 1980's. Nearly bullet proof.

But this design of having the dual tweeter drivers point in 2 different axes than the big driver, will end up with the loudest path coming by reflecting sound off of surfaces before getting to your ear.

You want the direct path from driver to ear to always be the shortest path when making mixing decisions, not a reflected path being loudest, which is what you would get with the 301 speakers.