Having the same problem with my Scarlett 4i2. Sort of have it figured out if I plug my strat directly into interface. But I have a rather expensive POD HD500 that I'd like to process my guitar signal. Everytime I try to use it via usb into my desktop and record into my DAW Power Tracks it sounds like crap. I think you're saying even though my HD500 is plugged via usb into desktop All my settings for devices should list the Scarlett 4i2 as botht he recording device and the playback device???? totally lost . . . .