Do a Google Search on "desktop icons missing windows 10"

There's plenty.

Although it's not only Win 10. Other versions have issues also. Mine have been OK.

Q:
Is your E: drive the removable Audiophile drive, or is that an internal drive?

If it's the removable drive and you started the computer without it being connected, this might have triggered the O/S to remove the link. Maybe.


BIAB & RB2025 Win.(Audiophile), Sonar Platinum, Cakewalk by Bandlab, Izotope Prod.Bundle, Roland RD-1000, Synthogy Ivory, Kontakt, Focusrite 18i20, KetronSD2, NS40M Monitors, Pioneer Active Monitors, AKG K271 Studio H'phones