Do a Google Search on "desktop icons missing windows 10"

There's plenty.

Although it's not only Win 10. Other versions have issues also. Mine have been OK.

Q:
Is your E: drive the removable Audiophile drive, or is that an internal drive?

If it's the removable drive and you started the computer without it being connected, this might have triggered the O/S to remove the link. Maybe.


BIAB & RB2026 Win.(Audiophile), Windows 10 Pro & Windows 11, Cakewalk Bandlab, Izotope Prod.Bundle, Roland RD-1000, Synthogy Ivory, Session Keys Grand S & Electric R, Kontakt, Focusrite 18i20, KetronSD2, NS40M, Pioneer Active Monitors.