I would DL and use these in this order:
1-RKill -
http://www.bleepingcomputer.com/download/rkill/make sure that you choose RKill. RKill means Root Kill and it works better than Malwarebytes root kill.
2-AdwCleaner -
http://www.bleepingcomputer.com/download/adwcleaner/This finds things that Malwarebytes can miss.
3- Malwarebytes - not the beta version
https://www.malwarebytes.com/mwb-download/4- your anti-virus
I have had to use these free programs on a couple of friends computers and they cleaned them perfectly.
The safest way to make a backup is to use a Acronis boot disk. But if the computer is infected then Acronis will copy the infection. I run RKill, Malwarebytes and Defender prior to backing up. I only add AdwCleaner if I am having a problem.
Good luck.