Many thanks to all for your suggestions.

Noel, Yes I run BB & RB directly from the PG USB drive (clicking .exe files from there too set as Administrator).
I'll try increasing the buffer size but have had some minor latency problems in Reaper with buffer sizes higher than 10ms. On the Focusrite I can direct monitor.... but prefer to monitor though Reaper (to be able to hear vocals with effects running through bus track). Just trying to get a happy medium so I'm not having to change buffer sizes for every job.

Kev


BIAB 2022 PLUSPAK (ext HD), 49PAKs, STYLESPAKs 1 - 6, Win 7 64bit PC, REAPER, Ozone, Adobe Audition CS6, EZ Drummer3 + EZ Keys,Soundcraft MTK22, Behringer X Touch Universal Controller,, SE Gemini/Rode NT2/Neumann/Shure mics