Scott,
I use Vista 64 Ultimate on my computer, and TTS-1 works on that, although I will admit that I haven't tried bank changes. I have a hardware synth that I use.
However, I've had issues with Sonar 7 running in 64 bit mode, so I run it in 32 bit mode. The problem is with my SOUND CARD DRIVERS and NOT SONAR! Once I get the sound card drivers updated for 64 bit, then I should be able to reinstall Sonar as a 64 bit app.
However, there are many applications, including Band In A Box, which are not 64 bit apps, and work very well on a 64 bit system. However, if you are trying to run a 64 bit program, everything must be 64 bits. So, depending on your sound card, it may be easier to run MC5 as a 32 bit app, and you shouldn't have any issue at all.
Gary